The Most Effective Natural Agent Against Cancer

Justus R. Hope
*Substack* | November 2, 2025
Posted by Twotone

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### Guy Tenenbaum’s Miraculous Journey: How a 42-Day Fast, Autophagy, and a Key Natural Supplement Beat Stage 4 Prostate Cancer

Two weeks ago, I asked Dr. Paul Marik what he thought about Guy Tenenbaum’s inexplicable recovery from Stage 4 prostate cancer, including the disappearance of bone metastases. We reviewed his case in detail, leading to discoveries that resulted in updating our Cancer Care Advanced Protocol. Among several changes, we revised fasting durations, inspired by Guy’s experience. However, my favorite addition is a widely available natural supplement I want to share with you today.

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### The Siege: Fighting Cancer by Starving it

Imagine your body as a city under siege. Cancer cells are invaders who have breached the city walls and entrenched themselves throughout the kingdom. In 2016, Guy Tenenbaum faced this grim reality—Stage 4 prostate cancer with a Gleason score of 9 (the most aggressive type), with metastases spread to his bones. Doctors gave a terminal prognosis; most men in his position would not survive 2-3 years.

But Guy refused to accept this.

He took a radical approach: he fasted for 42 days, took high doses of a key natural agent, and activated his body’s ancient survival mechanism called **autophagy**—teaching his cells to essentially “eat” the cancer.

Six years later, Guy is cancer-free, his bones healed, and his story is rewriting what we believed possible.

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### Understanding Autophagy: Your Body’s Recycling System

Autophagy, the 2016 Nobel Prize-winning process discovered by Japanese scientist Yoshinori Ohsumi, works like a city’s sanitation department.

– Under normal conditions, autophagy manages everyday cellular waste.
– During crisis (like Guy’s 42-day fast), autophagy goes into overdrive: clearing damaged cells, recycling misfolded proteins, and eliminating cancer cells.

Normal cells slow down metabolism—like hibernating bears—to survive fasting. Cancer cells, however, require constant feeding and cannot adapt. During his fast, Guy’s normal cells “waited it out,” while cancer cells starved to death.

This is not metaphorical—this is exactly what occurred on a cellular level.

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### The Key Supplement: Nature’s Multi-Tool Against Disease

Fasting created the battlefield; this natural agent provided the ammunition.

Scientists estimate it was responsible for approximately **30%** of Guy’s remarkable recovery. Evidence from clinical trials reveals why.

– In 2004, a large cancer prevention study with ~5,000 participants showed this agent reduced **stomach cancer incidence by 52%**, with the strongest effect in men.
– A 2019 follow-up published in a prestigious medical journal revealed participants who stopped taking this supplement 17 years earlier still had **34% lower cancer mortality**.

This supplement acts like a Swiss Army knife by attacking cancer through multiple mechanisms simultaneously:

1. **Reduces IGF-1 (Insulin-like Growth Factor-1):** Cancer cells need IGF-1 to grow; this agent cuts it off.
2. **Activates Autophagy:** Amplifies cancer cell clearance triggered by fasting.
3. **Suppresses NFκB:** A master switch controlling inflammation and cancer stem cell survival.
4. **Boosts Natural Killer (NK) Cells:** Enhances immune “assassins” by up to 300%.

In Guy’s case, fasting plus this supplement created an environment cancer cells couldn’t survive.

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### Beyond Cancer: Benefits for Aging, Heart Disease, and Brain Health

The mechanisms fighting cancer also impact aging and other diseases.

**Anti-Aging Benefits:**
A 2021 study found people on a supplement-rich methylation-optimized diet reversed biological age by over 3 years in just 8 weeks, measured by epigenetic clocks. This agent acts as a “methyl donor,” pressing the right genetic “pedals” to promote youth.

**Slowing Heart Disease Progression:**
A 2020 European study of 104 people found those taking the agent had a nearly 3-fold slower progression of coronary artery calcification. Another study showed it slowed arterial aging in firefighters by nearly 4 times.

**Brain Health:**
The agent restores SIRT1 activity, a longevity gene critical for neurogenesis, clearing toxic protein tangles (like β-amyloid in Alzheimer’s), and repairing DNA damage. It effectively “flips on” brain health switches destroyed by aging or radiation.

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### Why This Agent Beats Popular Alternatives Like EGCG and Curcumin

**Bioavailability:**
Curcumin, despite strong lab results, has only 1-5% absorption in humans. This agent boasts over **100% bioavailability**, meaning your body absorbs and retains it efficiently.

**Clinical Trial Success:**
– Curcumin succeeded in 3 of 7 major trials (43%), mainly in pre-cancerous conditions.
– Green tea extract (EGCG) failed in three major cancer prevention trials.
– Our key agent succeeded in **2 of 2 major trials (100%)**, with a much larger sample size (over 5,000 participants) and 22 years of follow-up.

This demonstrates real-world effectiveness beyond hopeful lab results.

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### Guy’s Protocol: Fasting + Supplement Synergy

– **42-day fast:** Water only, with occasional coffee or tea; maximized autophagy (over 11,000 times more effective than 16-hour intermittent fasting).
– **Supplement dosage:** 1,000 mg daily throughout fast and afterward.
– Additional metabolically active supplements were also included.

The fast reduced Guy’s IGF-1 by 85-95%, starving cancer. The supplement suppressed inflammation and boosted immune response. By the end of his fast, his PSA dropped from 58 to 0.1 and bone lesions healed.

Six years later, he remains cancer-free with healed bones—an outcome so rare leading to a foreword by Dr. Thomas Seyfried in Guy’s book.

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### The Bigger Picture: A New Paradigm in Cancer Care

Guy’s story challenges conventional cancer treatment, which often relies on chemotherapy and radiation. His approach was like a siege:

– Starve the cancer cells through fasting.
– Poison residual resources with a natural supplement.
– Enable the immune system to eliminate survivors.

The synergy of fasting plus supplement is more powerful than either alone.

Two major clinical trials at Johns Hopkins and Cedars-Sinai are now recruiting prostate cancer patients to study fasting and fasting-mimicking diets, inspired by Guy’s case. If confirmed, this could revolutionize cancer care with safe, cost-effective strategies.

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### Introducing the Key Supplement: Aged Garlic Extract (AGE)

#### What is Aged Garlic Extract?

Aged Garlic Extract (AGE) is not regular garlic or raw garlic. It’s crafted through a proprietary 20-month aging process that produces:

– A powerful, odorless, and bioavailable health supplement.
– Rich in stable, beneficial compounds unlike raw garlic.

#### Manufacturing Highlights:

– **Organic Cultivation:** Certified organic garlic grown in California.
– **20-Month Aging:** Room temperature aging without heat or fermentation, enhancing compound stability.
– **Extraction & Quality Control:** Extracted in ethanol solution, filtered under low temperature, with over 250 quality checks.

#### Advantages Over Raw Garlic:

– **Bioavailability:** Delivers 20-50 times more stable and bioactive compounds.
– **Active Compounds:** Contains beneficial S-allylcysteine (SAC), S-allylmercaptocysteine (SAMC), antioxidants, selenium, and saponins.
– **Odorless and Gentle:** No garlic breath, no irritation, and socially acceptable anytime.
– **Standardized & Consistent:** Uniform potency every bottle, ensuring reliable clinical effects.

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### Guy Tenenbaum’s Dose: 1,000 mg Per Day

– Used daily during and after his fast.
– Falls within the therapeutic window for cancer support.
– Well-tolerated with no reported side effects.
– Convenient: One capsule per day promotes compliance.

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### Where to Buy Aged Garlic Extract

**Primary Brand:** Kyolic (Original & Most Studied) by Wakunaga of America.

– Subject of over 870 peer-reviewed studies.
– Product: Kyolic Aged Garlic Extract One Per Day, Formula 250.
– Strength: 1,000 mg per vegetarian caplet.
– Organic, odorless, non-GMO certified.

**Recommended Purchase:**
– Online retailer iHerb offers a 60-count bottle (~2-month supply) for approximately $15–20 USD.
– [iHerb Kyolic Aged Garlic Extract 1,000 mg](https://www.iherb.com)

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### Final Thoughts

Guy Tenenbaum’s journey offers hope not only for cancer patients but for anyone aiming to optimize health and longevity using natural, science-backed interventions. The fact that an affordable supplement costing less than 50 cents per day contributed significantly to beating Stage 4 cancer underscores the potential of combining nature’s tools with modern knowledge.

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### Disclaimer

Opinions expressed are those of the author and do not necessarily reflect the views of any organizations mentioned. The information provided is for educational purposes and not intended as medical advice. Please consult a healthcare professional before starting any treatment.

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*Thank you for reading. God bless you.*

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